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Top-10 Cat Flea And Tick Preventions
Loved in the USA

Handpicked for quality & trusted by thousands of customers

Sponsored

NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#1
Top Rated in the USA
PetArmor P
PetArmor

Born in the USA

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Fast Delivery
10.0
56 827 reviews

Solid Value from a Trusted Brand

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1 454 bought in past month

Sponsored

NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#2
Seresto La
Seresto

Born in the USA

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. 2-Pack

Fast Delivery
8.8
109 765 reviews

Solid Value from a Trusted Brand

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1 352 bought in past month
Last Purchases
J***s
Philadelphia, PA
4d ago
Ga***el
Las Vegas, NV
1d ago
Ol***ia
Las Vegas, NV
1d ago
#3
Advantage
Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention Cats Over 9 lbs. 2-Month Supply

Fast Delivery
8.5
75 807 reviews

Solid Value from a Trusted Brand

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1 250 bought in past month
Top-tier quality for the cost.
OliviaNew York, NY
#4
Cheristin
Cheristin

Born in the USA

Cheristin Flea Treatment & Prevention for Cats Fast acting topical flea treatment for cats over 1.8 lbs 6 Count

Fast Delivery
8.2
21 509 reviews

Solid Value from a Trusted Brand

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1 148 bought in past month
Curated products trusted bytrust us brands
#5
Seresto Ca
Seresto

Born in the USA

Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats 8 Months Protection

Fast Delivery
7.9
42 926 reviews

Solid Value from a Trusted Brand

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1 046 bought in past month
#6
Advantage
Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention Cats 5-9 lbs. 4-Month Supply

Fast Delivery
7.9
37 539 reviews

Solid Value from a Trusted Brand

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944 bought in past month
#7
Capstar (n
Capstar

Born in the USA

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

Fast Delivery
7.6
39 058 reviews

Solid Value from a Trusted Brand

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842 bought in past month
#8
FRONTLINE
Frontline

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

11%OFF

Fast Delivery
7.3
48 172 reviews

Item still has Pre-Tariff price

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740 bought in past month
#9
Advecta Pl
Advecta

Born in the USA

Advecta Plus Flea Prevention for Cats, Cat and Kitten Treatment & Control, Small and Large, Fast Acting Waterproof Topical Drops, 6 Month Supply

Fast Delivery
7.0
11 707 reviews

Solid Value from a Trusted Brand

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638 bought in past month
#10
Revolution
Revolution Plus

Born in the USA

Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 11.1-22 lbs (Green), 6 Tubes

Fast Delivery
7.0
57 reviews

Solid Value from a Trusted Brand

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536 bought in past month

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PetArmor C
PetArmor

Born in the USA

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

Fast Delivery
16 647
verified reviews

Solid Value from a Trusted Brand

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434 bought in past month
Catego for
Catego

Catego for Cats Flea and Tick Treatment & Prevention (Over 1.5 lbs) 6-Month Supply

Fast Delivery
5 820
verified reviews

Solid Value from a Trusted Brand

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332 bought in past month
NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 3 Month Dose

Fast Delivery
1 334
verified reviews

Solid Value from a Trusted Brand

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230 bought in past month
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TevraPet F
TevraPet

Born in the USA

TevraPet FirstAct Plus Flea and Tick Prevention for Cats Over 1.5lbs, 6 Monthly Doses, Topical Drops

Fast Delivery
13 678
verified reviews

Solid Value from a Trusted Brand

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128 bought in past month
TevraPet A
TevraPet

Born in the USA

TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs 6 Doses Powerful Prevention and Control

Fast Delivery
17 759
verified reviews

Solid Value from a Trusted Brand

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26 bought in past month

Our Top Picks

#1

Winner

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Rating
10.0
Chosen by1,454
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
56827 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.

PetArmor Plus Flea and Tick Prevention for Cats is a topical treatment designed for cats weighing over 1.5 pounds and aged 8 weeks or older. It contains the active ingredients fipronil and (s)-methoprene, which work together to kill fleas, flea eggs, larvae, ticks, and chewing lice. One of its strong points is that it helps break the flea life cycle, which means it doesn't just kill adult fleas but also prevents new infestations by targeting eggs and larvae. The formula is waterproof and fast-acting, starting to work within 24 hours and providing protection for up to 30 days per application. The pack includes 12 doses, enough to cover a full year of monthly treatment. It’s easy to apply by parting the cat’s fur at the shoulder blades and squeezing on the drops. Because the product can leave a greasy residue for about two days, you might need to clean the area gently if it seems excessive.

PetArmor Plus is unscented and allergen-free, which is helpful for sensitive cats. While generally safe if used as directed, it’s important to keep treated cats away from other pets and children until the product dries. Some users have reported mild side effects like temporary irritation, but this is uncommon. This product suits cat owners looking for a reliable, veterinarian-quality flea and tick treatment that is straightforward to use and provides lasting protection. It may not be ideal if you prefer natural or oral treatments, or if your cat is under 1.5 pounds.

Rating
10.0
Chosen by1,454
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
56827 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.
#2

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 2-Pack

Rating
8.8
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
109765 reviews

Type of Prevention
The collar starts killing fleas quickly, often showing dead fleas the same day it’s applied, and can eliminate severe flea infestations inside the home.
Duration of Effectiveness
It provides long-lasting protection that reduces the need for monthly treatments, making it a cost-effective solution for flea and tick prevention.
Age and Weight Restrictions
Regularly checking the fit is important, especially for growing dogs, to maintain comfort and effectiveness.
Side Effects and Safety
Its design includes a safety feature that allows the collar to unlatch if caught, preventing injury, though it should not replace a walking collar.
Ease of Application
The collar is non-greasy, unscented, and comfortable, avoiding the mess and smell common with other topical treatments.

The Seresto Large Dog Flea & Tick Collar is a popular, vet-recommended option designed for dogs over 18 pounds. It uses active ingredients imidacloprid and flumethrin to kill and repel fleas and ticks by contact, so pests don't need to bite your dog for protection to work. This collar provides protection for up to 8 months, which means fewer treatments compared to monthly options. It's suitable for dogs as young as 7 weeks old, making it a flexible choice for both puppies and adult dogs.

The collar is easy to apply—just fit it around your dog's neck and trim any excess length for comfort. It is non-greasy and unscented, which helps avoid irritation or discomfort. Users appreciate its convenience and long-lasting effect, but it's important to check the fit regularly, especially for growing puppies. While generally safe, as with any chemical treatment, some dogs might experience mild side effects, so monitoring your pet initially is recommended.

The Seresto collar offers a hassle-free, effective solution for large dog owners seeking extended flea and tick prevention without frequent reapplication.

Rating
8.8
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
109765 reviews

Type of Prevention
The collar starts killing fleas quickly, often showing dead fleas the same day it’s applied, and can eliminate severe flea infestations inside the home.
Duration of Effectiveness
It provides long-lasting protection that reduces the need for monthly treatments, making it a cost-effective solution for flea and tick prevention.
Age and Weight Restrictions
Regularly checking the fit is important, especially for growing dogs, to maintain comfort and effectiveness.
Side Effects and Safety
Its design includes a safety feature that allows the collar to unlatch if caught, preventing injury, though it should not replace a walking collar.
Ease of Application
The collar is non-greasy, unscented, and comfortable, avoiding the mess and smell common with other topical treatments.
#3

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

Rating
8.5
Side Effects and Safety
Ease of Application

Most important from
75807 reviews

Side Effects and Safety
Excellent product, really works and doesn’t bother our cat at all.
Ease of Application
Fleas be gone! Easy to use and not as expensive as other products.

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention is specifically designed for large cats over 9 lbs and at least 8 weeks old. This product stands out as an easy-to-apply monthly topical treatment that eliminates the need for hard-to-swallow pills and does not require a prescription. It's effective against adult fleas, flea larvae, and flea eggs, providing comprehensive protection.

The treatment starts working within 12 hours of application and remains effective for 30 days, ensuring continuous flea control for a month. Additionally, it is fragrance-free and waterproof, making it suitable for cats' daily activities after 24 hours of application. The active ingredients, Imidacloprid and Pyriproxyfen, are known for their efficacy in flea control.

It is crucial to follow the application instructions carefully to avoid any adverse effects, such as getting the product in the cat's eyes or ingestion. While the product is generally safe, some cats might experience mild side effects like skin irritation. The ease of application is greatly appreciated by pet owners, as it simplifies the process of flea prevention. This product is highly recommended for large cats who need reliable and effective flea treatment without the hassle of pills.

Rating
8.5
Side Effects and Safety
Ease of Application

Most important from
75807 reviews

Side Effects and Safety
Excellent product, really works and doesn’t bother our cat at all.
Ease of Application
Fleas be gone! Easy to use and not as expensive as other products.

Buying Guide for the Best Cat Flea And Tick Preventions

Choosing the right flea and tick prevention for your cat is crucial for their health and comfort. Fleas and ticks can cause a range of issues from mild irritation to serious diseases. When selecting a product, consider your cat's lifestyle, health status, and any specific needs they may have. It's important to understand the different types of preventions available and how they work to make an informed decision that best suits your cat's needs.
Type of PreventionFlea and tick preventions come in various forms such as topical treatments, oral medications, collars, and shampoos. Topical treatments are applied directly to the cat's skin and are effective for a month. Oral medications are ingested and can provide protection for up to three months. Collars release active ingredients over time and can last for several months. Shampoos provide immediate relief but need to be used regularly. Choose the type based on your cat's tolerance and your convenience.
Active IngredientsThe active ingredients in flea and tick preventions are what kill or repel the pests. Common ingredients include fipronil, imidacloprid, and fluralaner. Each ingredient works differently and may target different stages of the flea or tick lifecycle. It's important to choose a product with ingredients that are safe for cats and effective against the specific pests in your area. Consult your vet to determine which active ingredients are best for your cat.
Duration of EffectivenessThe duration of effectiveness refers to how long the prevention will protect your cat from fleas and ticks. This can range from a few days with shampoos to several months with collars. Consider how often you are willing to reapply or administer the prevention. For busy pet owners, longer-lasting options like collars or oral medications might be more convenient.
Age and Weight RestrictionsMany flea and tick preventions have age and weight restrictions to ensure safety and effectiveness. Products are often formulated for specific age groups, such as kittens or adult cats, and weight ranges. Always check the product label to ensure it is appropriate for your cat's age and weight. Using a product not suited for your cat can lead to ineffective treatment or potential health risks.
Side Effects and SafetyAll flea and tick preventions have the potential for side effects, which can range from mild skin irritation to more serious reactions. It's important to read the product label and consult with your vet about any potential side effects, especially if your cat has a history of allergies or sensitivities. Choose a product with a good safety profile and monitor your cat for any adverse reactions after application.
Ease of ApplicationThe ease of application can vary significantly between different types of flea and tick preventions. Topical treatments and collars are generally easy to apply, while oral medications may require more effort if your cat is resistant to taking pills. Shampoos require regular bathing, which can be challenging if your cat dislikes water. Consider your cat's temperament and your ability to administer the treatment when choosing a product.

FAQ