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Top-10 Cat Flea And Tick Preventions
Loved in the USA

Handpicked for quality & trusted by thousands of customers

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NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#1
Top Rated in the USA
PetArmor P
PetArmor

Born in the USA

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

19%OFF

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10.0
57 764 reviews

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1 149 bought in past month

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NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent, and Control, Fast Acting Waterproof Topical Drops for Cats Over 3.5 lbs, 6 Month Dose

#2
Seresto La
Seresto

Born in the USA

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. 2-Pack

9%OFF

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10.0
110 636 reviews

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1 047 bought in past month
Last Purchases
Vi***or
Boston, MA
3d ago
Je***er
New York, NY
2d ago
Be***in
Atlanta, GA
1d ago
#3
Capstar (n
Capstar

Born in the USA

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 12 Doses (Includes Two 6-Count Boxes)

Fast Delivery
9.7
39 520 reviews

Solid Value from a Trusted Brand

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945 bought in past month
Good materials and workmanship at a great rate.
HarperPortland, OR
#4
Seresto Ca
Seresto

Born in the USA

Seresto Cat Vet-Recommended Flea & Tick Treatment & Prevention Collar for Cats, 8 Months Protection (Pack of 2)

Fast Delivery
9.4
43 324 reviews

Solid Value from a Trusted Brand

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843 bought in past month
Curated products trusted bytrust us brands
#5
FRONTLINE
Frontline

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 6 Treatments

Fast Delivery
9.4
48 564 reviews

Solid Value from a Trusted Brand

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741 bought in past month
#6
Capstar (n
Capstar

Born in the USA

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 6 Doses

5%OFF

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8.8
39 520 reviews

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639 bought in past month
#7
Advantage
Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention Cats Over 9 lbs. 2-Month Supply

5%OFF

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8.5
63 169 reviews

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537 bought in past month
#8
Revolution
Revolution Plus

Born in the USA

Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 11.1-22 lbs (Green), 6 Tubes

5%OFF

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7.9
75 reviews

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435 bought in past month
#9
PetArmor C
PetArmor

Born in the USA

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

5%OFF

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7.3
16 983 reviews

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333 bought in past month
#10
Catego for
Catego

Catego for Cats Flea and Tick Treatment & Prevention (Over 1.5 lbs) 6-Month Supply

7%OFF

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7.0
5 890 reviews

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231 bought in past month

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Revolution
Revolution Plus

Born in the USA

Revolution Plus (selamectin and sarolaner Topical Solution) for Cats, 5.6-11 lbs (Orange), 3 Tubes

5%OFF

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75
verified reviews

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129 bought in past month
Advecta Pl
Advecta

Born in the USA

Advecta Plus Topical Large Cat Flea Treatment for Cats and Kittens, Flea Prevention and Control, Fast-Acting Waterproof Drops, 6-Month Supply

25%OFF

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11 953
verified reviews

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27 bought in past month
Advantage
Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention Cats 5-9 lbs. 2-Month Supply

5%OFF

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12 347
verified reviews

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NEXTSTAR F
NEXTSTAR

NEXTSTAR Flea and Tick Prevention for Cats, Repellent and Control, Fast Acting Waterproof Topical Drops, Flea Prevention for Cats Over 3.5 lbs, 3 Monthly Doses

25%OFF

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1 518
verified reviews

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TevraPet A
TevraPet

Born in the USA

TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs 6 Doses Powerful Prevention and Control

15%OFF

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17 959
verified reviews

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Our Top Picks

#1

Winner

PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Rating
10.0
Chosen by1,149
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
57764 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.

PetArmor Plus Flea and Tick Prevention for Cats is a topical treatment designed for cats weighing over 1.5 pounds and aged 8 weeks or older. It contains the active ingredients fipronil and (s)-methoprene, which work together to kill fleas, flea eggs, larvae, ticks, and chewing lice. One of its strong points is that it helps break the flea life cycle, which means it doesn't just kill adult fleas but also prevents new infestations by targeting eggs and larvae. The formula is waterproof and fast-acting, starting to work within 24 hours and providing protection for up to 30 days per application. The pack includes 12 doses, enough to cover a full year of monthly treatment. It’s easy to apply by parting the cat’s fur at the shoulder blades and squeezing on the drops. Because the product can leave a greasy residue for about two days, you might need to clean the area gently if it seems excessive.

PetArmor Plus is unscented and allergen-free, which is helpful for sensitive cats. While generally safe if used as directed, it’s important to keep treated cats away from other pets and children until the product dries. Some users have reported mild side effects like temporary irritation, but this is uncommon. This product suits cat owners looking for a reliable, veterinarian-quality flea and tick treatment that is straightforward to use and provides lasting protection. It may not be ideal if you prefer natural or oral treatments, or if your cat is under 1.5 pounds.

Rating
10.0
Chosen by1,149
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
57764 reviews

Type of Prevention
Effectively kills adult fleas, flea eggs, larvae, ticks, and chewing lice, breaking the entire flea life cycle.
Duration of Effectiveness
Starts working within 24 hours and provides reliable protection for up to 30 days per application.
Age and Weight Restrictions
Not ideal for cats under 1.5 pounds or those who prefer natural or oral treatment options.
Side Effects and Safety
Unscented and allergen-free, making it suitable for cats with sensitive skin.
Ease of Application
Application is straightforward and hassle-free, simply part the fur and apply at the shoulder blades.
#2

Seresto Large Dog Vet-Recommended Flea & Tick Treatment & Prevention Collar for Dogs Over 18 lbs. | 2-Pack

Rating
10.0
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
110636 reviews

Type of Prevention
The collar starts killing fleas quickly, often showing dead fleas the same day it’s applied, and can eliminate severe flea infestations inside the home.
Duration of Effectiveness
It provides long-lasting protection that reduces the need for monthly treatments, making it a cost-effective solution for flea and tick prevention.
Age and Weight Restrictions
Regularly checking the fit is important, especially for growing dogs, to maintain comfort and effectiveness.
Side Effects and Safety
Its design includes a safety feature that allows the collar to unlatch if caught, preventing injury, though it should not replace a walking collar.
Ease of Application
The collar is non-greasy, unscented, and comfortable, avoiding the mess and smell common with other topical treatments.

The Seresto Large Dog Flea & Tick Collar is a popular, vet-recommended option designed for dogs over 18 pounds. It uses active ingredients imidacloprid and flumethrin to kill and repel fleas and ticks by contact, so pests don't need to bite your dog for protection to work. This collar provides protection for up to 8 months, which means fewer treatments compared to monthly options. It's suitable for dogs as young as 7 weeks old, making it a flexible choice for both puppies and adult dogs.

The collar is easy to apply—just fit it around your dog's neck and trim any excess length for comfort. It is non-greasy and unscented, which helps avoid irritation or discomfort. Users appreciate its convenience and long-lasting effect, but it's important to check the fit regularly, especially for growing puppies. While generally safe, as with any chemical treatment, some dogs might experience mild side effects, so monitoring your pet initially is recommended.

The Seresto collar offers a hassle-free, effective solution for large dog owners seeking extended flea and tick prevention without frequent reapplication.

Rating
10.0
Type of Prevention
Duration of Effectiveness
Age and Weight Restrictions

Most important from
110636 reviews

Type of Prevention
The collar starts killing fleas quickly, often showing dead fleas the same day it’s applied, and can eliminate severe flea infestations inside the home.
Duration of Effectiveness
It provides long-lasting protection that reduces the need for monthly treatments, making it a cost-effective solution for flea and tick prevention.
Age and Weight Restrictions
Regularly checking the fit is important, especially for growing dogs, to maintain comfort and effectiveness.
Side Effects and Safety
Its design includes a safety feature that allows the collar to unlatch if caught, preventing injury, though it should not replace a walking collar.
Ease of Application
The collar is non-greasy, unscented, and comfortable, avoiding the mess and smell common with other topical treatments.
#3

Capstar (nitenpyram) Cat Flea Treatment, Fast-Acting Oral Flea Treatment for Cats 2-25 lbs, Vet-Recommended Medication Tablets Start Killing in 30 Minutes, 12 Doses (Includes Two 6-Count Boxes)

Rating
9.7
Type of Prevention
Ease of Application
Age and Weight Restrictions

Most important from
39520 reviews

Type of Prevention
Starts killing adult fleas within 30 minutes, providing fast and effective relief.
Ease of Application
Easy to administer, either directly or hidden in food, which cats tolerate well.
Age and Weight Restrictions
Safe for cats and kittens as young as four weeks old, offering peace of mind.
Duration of Effectiveness
Best used alongside longer-lasting flea treatments since it only targets adult fleas.
Side Effects and Safety
Some cats may experience bursts of energy followed by lethargy, but these effects are temporary.

Capstar (nitenpyram) is an oral flea treatment designed specifically for cats weighing between 2 to 25 pounds. Its main strength lies in its speed—it starts killing adult fleas within 30 minutes, which is great if you need quick relief for your pet. The active ingredient, nitenpyram, targets only adult fleas and is considered safe for cats and kittens as young as four weeks old. This makes it a versatile option for households with younger pets. Another benefit is that Capstar is available over the counter and can be given daily if fleas return, providing flexible flea control.

However, Capstar’s effect is short-lived—it only kills existing adult fleas and does not prevent new infestations or target flea eggs or larvae. This means you will likely need to use it alongside other products that provide longer-lasting protection to fully manage fleas on your cat. As it’s given in tablet form, it’s fairly easy to administer either directly or hidden in food, which many cats tolerate well. There are no reported strong side effects, but as with any medication, some cats might have mild reactions.

Capstar serves as an effective fast-acting solution for immediate flea relief and is safe for most cats, including kittens. It performs best as a quick fix or as part of a broader flea control routine rather than a stand-alone, long-term prevention method.

Rating
9.7
Type of Prevention
Ease of Application
Age and Weight Restrictions

Most important from
39520 reviews

Type of Prevention
Starts killing adult fleas within 30 minutes, providing fast and effective relief.
Ease of Application
Easy to administer, either directly or hidden in food, which cats tolerate well.
Age and Weight Restrictions
Safe for cats and kittens as young as four weeks old, offering peace of mind.
Duration of Effectiveness
Best used alongside longer-lasting flea treatments since it only targets adult fleas.
Side Effects and Safety
Some cats may experience bursts of energy followed by lethargy, but these effects are temporary.

Buying Guide for the Best Cat Flea And Tick Preventions

Choosing the right flea and tick prevention for your cat is crucial for their health and comfort. Fleas and ticks can cause a range of issues from mild irritation to serious diseases. When selecting a product, consider your cat's lifestyle, health status, and any specific needs they may have. It's important to understand the different types of preventions available and how they work to make an informed decision that best suits your cat's needs.
Type of PreventionFlea and tick preventions come in various forms such as topical treatments, oral medications, collars, and shampoos. Topical treatments are applied directly to the cat's skin and are effective for a month. Oral medications are ingested and can provide protection for up to three months. Collars release active ingredients over time and can last for several months. Shampoos provide immediate relief but need to be used regularly. Choose the type based on your cat's tolerance and your convenience.
Active IngredientsThe active ingredients in flea and tick preventions are what kill or repel the pests. Common ingredients include fipronil, imidacloprid, and fluralaner. Each ingredient works differently and may target different stages of the flea or tick lifecycle. It's important to choose a product with ingredients that are safe for cats and effective against the specific pests in your area. Consult your vet to determine which active ingredients are best for your cat.
Duration of EffectivenessThe duration of effectiveness refers to how long the prevention will protect your cat from fleas and ticks. This can range from a few days with shampoos to several months with collars. Consider how often you are willing to reapply or administer the prevention. For busy pet owners, longer-lasting options like collars or oral medications might be more convenient.
Age and Weight RestrictionsMany flea and tick preventions have age and weight restrictions to ensure safety and effectiveness. Products are often formulated for specific age groups, such as kittens or adult cats, and weight ranges. Always check the product label to ensure it is appropriate for your cat's age and weight. Using a product not suited for your cat can lead to ineffective treatment or potential health risks.
Side Effects and SafetyAll flea and tick preventions have the potential for side effects, which can range from mild skin irritation to more serious reactions. It's important to read the product label and consult with your vet about any potential side effects, especially if your cat has a history of allergies or sensitivities. Choose a product with a good safety profile and monitor your cat for any adverse reactions after application.
Ease of ApplicationThe ease of application can vary significantly between different types of flea and tick preventions. Topical treatments and collars are generally easy to apply, while oral medications may require more effort if your cat is resistant to taking pills. Shampoos require regular bathing, which can be challenging if your cat dislikes water. Consider your cat's temperament and your ability to administer the treatment when choosing a product.

FAQ